How CBD can Help on Your First Legal Mushroom Trip


Last week, Oakland became the second city in the US to decriminalize “magic mushrooms.” Going a step further than Denver, Oakland has also decriminalized all plants with natural hallucinogenic properties such as the San Pedro Cactus.

While psilocybin mushrooms remain a schedule 1 controlled substance federally, on a state level and even locally in Oakland and Denver, they have been designated as the “lowest law enforcement priority.” This means that no taxpayer money can be spent investigating or prosecuting simple possession of these plant-based hallucinogens.

Ok, so mushrooms aren’t technically legal yet and your first fully-legal trip in America could be years out, but CBD is still a great travel companion for any kinda-sorta-legal mushroom experiences you have in the meantime.

CBD & Psilocybin

Cannabidol (CBD) and Psilocybin are peas in a psychedelic neurotransmitter pod. Each of these compounds stimulate communication between two vitally interrelated neural networks: the endocannabinoid system and the serotonergic system.

Endocannabinoid System - Absorbs cannabinoids (CBD, THC, etc.) and endocannabinoids via CB1 and CB2 receptors throughout the body.   

Serotonergic System - Absorbs serotonin and serotonin-binding molecules (like psilocybin) via 5-HT1A and 5-HT2A receptors concentrated in the digestive and nervous systems.

These interrelated systems are responsible for regulating a diverse range of behaviors and bodily functions like:

  • Sleep

  • Learning

  • Aggression

  • Appetite

  • Cognition

  • Decreasing nausea and headaches

  • Decreasing anxiety

  • Decreasing pain

  • Regulating body temperature

A growing body of research suggests that CBD interacts as much with the serotonergic system as it does with the endocannabinoid system, binding with serotonin receptors to produce similar effects to its interaction with the endocannabinoid system. 

According to Project CBD:

CBD activation of the 5-HT1A receptor has been shown to decrease blood pressure, lower body temperature, slow the heart rate, and lessen pain.

Psilocybin and CBD are also similar in that:

  • They are being researched as an effective means for quitting smoking and treating other addictions.

  • They are being researched in connection with treatment of depression, PTSD, OCD and other disorders.

  • They are being researched in connection with reduction of pain, psilocybin specifically in the cessation of cluster headaches, the worst form of migraines.

How CBD Helps You Have a Good Mushroom Trip

What makes a good trip?

Is it a great distance traveled in high spirits? A magical experience shared with good friends? The discovery of new things in the world and inside yourself?

The answer to this question is subjective, and so is the definition of a “bad trip.”

A bad trip can generally be understood as either:

  • A hallucinogenic experience that is too strong and/or difficult for an individual.

  • A trip that is generally negative and/or accompanied by high levels of anxiety.

  • Or (our preferred description)... A trip with “rough moments” in which difficult subjects are confronted.

Just as is the case in life, many of these rough moments are triggered by anxiety, but these moments can be experiences that result in personal (or group) growth.

CBD is incredibly helpful for people suffering from anxiety, but it also has been shown to “turn down” the intensity of your trip by antagonizing the receptors that make you hallucinate. This makes CBD a great companion for your first mushroom trip or any mushroom trip, really.

Here’s how CBD helps you have a good trip:

  • CBD has anxiolytic properties, meaning that it reduces anxiety by limiting your uptake of stress chemicals like cortisol.

  • CBD helps reduce nausea, a common side effect of psilocybin mushrooms.

  • CBD is an antagonist to 5-HT2A receptors (the ones that make you trip), meaning that it can “turn down” the intensity of your trip.

How to Have a Good Mushroom Trip

No matter how legal your next mushroom trip is, we want you to have a good time.

Whether you’re trekking through the woods, vibing at a concert, or painting in your room, follow these simple tips to make sure you’re having a positive and safe experience:

  1. Plan to be in a setting you love.

  2. Make sure you’re prepared for your journey mentally (well rested and centered) and physically (you have the right clothes, shoes, and supplies for your journey).

  3. Always dose according to your experience and comfort level (a little bit goes a long way).

  4. Bring some good friends (or make plans to meet up after your solo journey).

  5. Don’t do anything stupid or dangerous (like driving a car).

  6. Bring CBD to help you relax before, during, and/or after your trip.

Whether you are new to mushrooms and don’t know what to expect or are a seasoned psychonaut who wants to push their limits, CBD is a great companion to have on your journey.

Because low temperature vapor is the most readily bioavailable form of CBD, we recommend bringing effective CBD vape products on your next trip because they are handy for adventures, are fast acting & easy to dose (especially while tripping). Besides providing you with instant relief on a chemical level, gently inhaling aromatic vapor is calming in and of itself.

This way, you can be prepared for any tough moments that come your way during your next trip or simply have a healthier alternative to smoking to enjoy along the way.  


Our mission is to inspire further exploration of the mind through the delivery of information & Plant-Based Experiences.

Please join us on our mission and help us shine light on this topic by sharing your experiences (and this article) with others.



To celebrate Oakland and Denver for decriminalizing mushrooms in 2019, you can use this code until July 5th to get 11% off of your next order at

Promo code:  mushroom11

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